Everything about Conolidine alkaloid for chronic pain
Most lately, it's been identified that conolidine and the above derivatives act around the atypical chemokine receptor three (ACKR3. Expressed in identical regions as classical opioid receptors, it binds to a big selection of endogenous opioids. Unlike most opioid receptors, this receptor acts for a scavenger and doesn't activate a 2nd messenger pr